Category Archives: Research

Molecular Machines within us: The human neutrophil collagenase MMP8

Human neutrophil collagenase (HNC, MMP8) is one of the target enzymes for drug treatment of pathologic extracellular matrix degradation. Peptidomimetic inhibitors bind in the S-side of the enzyme active site occupying the S1 primary specificity pocket by their large hydrophobic … Continue reading

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Molecular Machines within us: The Carbon Monoxide Migration in Sperm Whale Myoglobin

Myoglobin is a small ancient protein of ~150 amino acids specialized in the transport of respiratory gases to muscular tissues and back to the lungs of the superior organisms. Even though, it was one of the first protein having the three-dimensional … Continue reading

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Molecular Machines within us: The Nucleosome core particle

The nucleosome core particle (NCP) constitutes the basic structural unit of the eukaryotic chromatin. It consists of 147 base-pairs (bp) of DNA wrapped in a left-handed superhelix 1.65 times around a histone octamer. The octamer is formed by two copies … Continue reading

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The β-lactamases TEM-1

β-lactamases are enzymes produced by bacteria (also known as penicillinase) that provide multi-resistance to β-lactam antibiotics such as penicillins, cephamycins, and carbapenems. 

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Molecular Machines within us: The Citrate Synthase I

The citrate synthase is a model enzyme for the study of the dynamics of domain motions.  It is a key protein in the metabolic cycle of the cell (Krebs cycle) as it catalyzes the Claisen condensation of acetyl-coenzyme A with … Continue reading

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Molecular Machines within us: The Glutamate Synthase

Glutamate Synthases are key enzymes in the early stages of the assimilation of ammonia in bacteria, yeast, and plants. Azospirillum brasilense glutamate synthase (GltS) is a complex iron-sulfur flavoprotein that catalyzes the reductive transfer of L-glutamine amide group to the (C2) … Continue reading

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Molecular Machines within us: Folding/Unfolding Mechanism of the Cytochrome c

The Cytochrome c (Cytc) is a small heme protein of ~100 amino acids. It presents in the mitochondrion of eukaryotic cells and it is loosely associated with their inner membrane. Cytc is highly water-soluble and is an essential component of … Continue reading

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