Category Archives: Research

Molekulare Maschinen: Die Coronavirus SARS-CoV-2 Bedrohung, Teil I.

Posted on May 5, 2020 by

Was Freunde mit und für uns tun, ist auch ein Erlebtes; denn es stärkt und fördert unsere Persönlichkeit. Was Feinde gegen uns unternehmen, erleben wir nicht, wir erfahren’s nur, lehnen’s ab und schützen uns dagegen wie gegen Frost, Sturm, Regen … Continue reading →

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Le Macchine Molecolari: La minaccia de Coronavirus SARS-CoV-2

Posted on April 25, 2020 by

Difficilmente è vinto colui che sa conoscere le forze sue e quelle del nemico. Nicollò Machiavelli in Dell’arte della guerra (1519-1520) Un virus è la vita nella forma più semplice. È la riduzione minimalista di un organismo ai suoi elementi … Continue reading →

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Molecular Machines: the Coronavirus SARS-CoV-2 Menace

Posted on March 5, 2020 by

“If you know the enemy and know yourself, you need not fear the result of a hundred battles. If you know yourself but not the enemy, for every victory gained you will also suffer a defeat. If you know neither … Continue reading →

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A personal tribute to the founder of MD simulation of biological molecules: Prof Herman J.C. Berendsen (1934-2019)

Posted on October 23, 2019 by

On the 7 October 2019, Prof Dr Herman Johan Christiaan Berendsen passed away just shortly after his 85 birthday. Prof Berendsen is considered the founder of the molecular dynamics simulation of biological system: the area of theoretical research that also … Continue reading →

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The Almighty​ Curcumin

Posted on September 22, 2018 by

Curcumin is a polyphenol derived from the root of turmeric (Curcuma longa) that it is widely used as a dietary spice and natural food colouring agent throughout the world.

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Modular Assembly of Proteins on Nanoparticles

Posted on April 25, 2018 by

I have recently contributed to a proof of concept study published in the prestigious Nature Communication (doi:10.1038/s41467-018-03931-4) [1]. The study involved collaborations with experimental groups across the University of Lincoln (UoL), University of Molise (Italy) and the Royal Holloway University … Continue reading →

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The Protein Engineering of a controllable Nano-Gate: the FhuA D1– 160 channel

Posted on March 28, 2018 by

The confinement of primeval biochemical compounds by nano compartmentalization made possible the spatial and temporal control and the development possible the most complex chemical process: the life.

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Bioinformatics Tools for Protein Engineering​: The MAP server

Posted on March 23, 2018 by

Mutagenesis Assistant Program (MAP) is a free accessible statistical tool which can be used for the benchmarking of random mutagenesis methods on the protein level. The server is currently hosted at the RTWH Aachen but it can still be accessed … Continue reading →

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The Arginine Deiminase​: an Anticancer Protein

Posted on March 23, 2018 by

Arginine deiminase (ADI, EC 3.5.3.6) is an arginine-metabolizing hydrolase that catalyzes the hydrolysis of the amino acid L-arginine to form citrulline and ammonia.

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Il calcolo delle cariche parziali atomiche

Posted on January 29, 2018 by

Le cariche parziali da usare nel campo di forze si ottengono generalmente da calcoli quantomeccanici. Nel caso di molecole rigide, il calcolo delle cariche è abbastanza semplice. Nel caso di molecole flessibili, occorre valutare quanto le diverse conformazioni influenzano la … Continue reading →

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