Protein Engineering​ and Directed Evolution




  1. A. Shivange, U. Schwaneberg, D. Roccatano. Conformational dynamics of active site loop in Escherichia coli phytase. Biopolymers. 93(11), 994–1002, (2010).

Monooxygenase P450 BM3


  1. S. Wong, N. Wu, D. Roccatano, M. Zacharias and U. Schwaneberg. Sensitive assay for laboratory evolution of hydroxylases toward aromatic and heterocyclic compounds. J. Biomol. Screen, 10, 246-252 (2005).
  2. Nazor, S. Dannennmann, R. Obeg Adjei, Y. B. Fordjour, T. I. Ghampson, M. Blanusa, D. Roccatano, U. Schwaneberg. Laboratory evolution of P450 BM3 for mediated electron transfer yields and activity-improved & reductase-independent variant. Protein Eng. Des. Sel., 21(1), 29-35, (2008).
  3. K. L. Tee, D. Roccatano, S. Stolte, J. Arning, B. Jastorff, U. Schwaneberg. Ionic liquids as cosolvents for biotransformation catalyzed by P450 BM-3. Green Chem., 10, 117-123, (2008).

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